HORDB

ID: hor004585
Uniprot ID: P62327??2-5)
Protein name: Hematopoietic system regulatory peptide
Gene name: TMSB4
Organism: Equus caballus (Horse)
Family: Thymosin beta family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Equus (genus), Equidae (family), Perissodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003779 actin binding; GO:0003785 actin monomer binding
GO BP: GO:0007015 actin filament organization; GO:0030334 regulation of cell migration; GO:0042989 sequestering of actin monomers
GO CC: GO:0005737 cytoplasm; GO:0005856 cytoskeleton

Function: Inhibits the entry of hematopoietic pluripotent stem cells into the S-phase
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: 80 minutes; /4800 seconds ( PubMed ID: 8257427 )

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004585_AF2.pdb

hor004585_ESM.pdb

Mass:	49916	Formula:	C18H31N5O8
Absent amino acids:	ACEFGHILMNQRTVWY	Common amino acids:	DKPS
pI:	6.34	Basic residues:	1
Polar residues:	1	Hydrophobic residues:	0
Hydrophobicity:	-245	Boman Index:	-1767
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	0
Instability Index:	-3257.5	Extinction Coefficient cystines:	0
Absorbance 280nm:	0